7 hours Ago By Connor Reid
ou may have wanted to or one that makes you feel sad or uneasy. You may also have experienced the opposite, suffering from memory loss or not remembering key elements of a story. Some memories can be very painful and tend to remain latent in our brains.
And, although we have always had to learn to deal with these experiences in our lives or to seek preventive treatments to avoid neuronal degeneration, we may be on the verge of a new solution following advances in the field of neuroscience. But we could also be on the verge of a new breakthrough in the search for a remedy for Alzheimer's disease The enzyme linked to memory loss Science is focused on specific areas, such as In this regard, a finding has attracted attention in recent months. This was published in Molecular Neurodegeneration and comes from researchers at the Institute of Basic Sciences According to this study, the cells present in the brain known as astrocytes are responsible for removing toxic plaques; however, in this process they produce GABA and hydrogen peroxide.
To put it simply, This is how neuronal connections end up degrading in a self-perpetuating process To understand how to break this vicious circle, the researchers tried to find out which were the necessary agents during this process and to inhibit or eliminate them without damaging other brain functions. After a series of processes, they managed to isolate two enzymes considered key in this action that are SIRT2 and ALDH1A1. The first was detected at very high levels in both mice and humans after death.
This indicates that it could be present in the processes that are responsible for cognitive impairment. In addition, it is important to note that SIRT2 acted mainly in the late stages of GABA production, which could determine that neuronal degeneration could continue even by inhibiting this protein Other implications of SIRT2 Although the most recent finding is the involvement of this protein in Alzheimer's disease, there have been other discoveries surrounding SIRT2 In relation to , blocking SIRT2 could lead to increased inflammation and insulin resistance. According to an article published by Dr.
Joan S. Fuster, On the other hand, in relation to the inhibition of SIRT2 in mice, a was observed. In fact, it was revealed that in the mice studied, Although this is encouraging, the researchers themselves acknowledge that even more questions arose after these discoveries Although SIRT2 may not be a direct pharmacological target because its effects on neurodegeneration appear to be rather limited, these findings open the door to many therapeutic strategies for diseases such as Alzheimer's.
