2 days Ago By [email protected] (Elaine Blackburne)
A simple blood test could reveal the biological age of a person's organs leading the way in treating them before they fall ill. Researchers say the discovery could predict the progression of diseases such as Alzheimer's as well as heart conditions. Scientists carrying out the US study discovered that individuals with organs ageing faster than their other body parts were more likely to develop conditions in those specific organs within 15 years.
The Stanford University, California team applied machine learning to evaluate protein levels in human blood samples. They focused on 11 key organs, organ systems or tissues, including the brain, heart, lung, kidney, liver, pancreas and intestine. They also looked at the immune system, muscle, fat and vasculature.
To train their algorithm, the investigators looked at nearly 5,000 proteins found in the blood of 1,398 healthy subjects from the Knight Alzheimer's Disease Research Centre. The subjects ranged from 20 to 90 years old but were predominantly in the mid to late stages of life. They highlighted the proteins which had genes which were four times more highly activated in one organ compared with others.
They found 858 organ-specific proteins and trained the algorithm to estimate a person's age based on them. Professor Tony Wyss-Coray, a neurology expert and the DH Chen Professor II at Stanford University and the senior author of the study, said: "We can estimate the biological age of an organ in an apparently healthy person. That, in turn, predicts a person's risk for disease related to that organ.
" Overall, the team tested their algorithm on 5,676 patients across five cohorts. The results, published in Nature, showed almost 20% of patients showed "strongly accelerated age" in one organ, while 1.7% showed ageing in multiple organs.
Researchers said accelerated organ ageing "confers a 20-50% higher mortality risk". Those with accelerated heart ageing were 250% more likely to have heart failure, while accelerated brain and vascular ageing could predict Alzheimer's progression better than the best current blood-based biomarker. Professor Wyss-Coray added: "If we can reproduce this finding in 50,000 or 100,000 individuals it will mean that by monitoring the health of individual organs in apparently healthy people, we might be able to find organs that are undergoing accelerated ageing in people's bodies, and we might be able to treat people before they get sick.
" Dr Leah Mursaleen, head of research at Alzheimer's Research UK, said of the study: "The diseases that cause dementia – like Alzheimer's – can begin in the brain decades before symptoms appear. New treatments on the horizon have only been shown to work in the early stages of Alzheimer's, which is why we need to find simple methods to accurately identify those most at risk of developing the disease. "This study suggests that looking at what's in our blood can provide a vital 'window' to look at what's happening deeper inside our body – including at the level of individual organs like the brain.
It shows that markers in the blood can measure brain and blood vessel ageing and could potentially be used to predict Alzheimer's and its progression. "While this science is at an early stage, it has the potential to add to our growing toolkit of blood-based detection methods, many of which are edging closer to routine use. It's likely that we'll see the first blood tests for Alzheimer's disease arrive on the NHS within the next five years.
"The development of even more accurate and less invasive methods to detect signs of age-related disease, including the earliest signs and progression of Alzheimer's, will take us closer to curing them. "Further work in this area is needed to develop and validate tools such as these, to help us get one step ahead of dementia.".
