ROCKVILLE, MD (April 10, 2025)—The April 2025 issue of FASEB BioAdvances features a comprehensive review on the impact of global warming on obesity, examining how external heat exposure modulates energy balance. This issue also includes research articles that explore the combined effects of hydrochlorothiazide and exercise training on blood pressure variability and renal dysfunctions, identify the role of Fosb in acute kidney injury through network expression analysis, and characterize gene recombination activity in neural and non-neural tissues using a novel Rbfox3-IRES-iCre knock-in mouse model. Additionally, a perspective piece discusses the integration of AI, biomedical informatics, and clinical medicine in advancing holistic precision wellness and next-generation precision medicine.
REVIEW ARTICLE Global warming and obesity: External heat exposure as a modulator of energy balance RESEARCH ARTICLES Hydrochlorothiazide combined with exercise training attenuates blood pressure variability and renal dysfunctions in an experimental model of hypertension and ovarian hormone deprivation Network expression analysis identifies and experimentally validates the involvement of Fosb in acute kidney injury Characterization of the Rbfox3 -IRES-iCre knock-in mouse: Revealing gene recombination activity in neural and non-neural peripheral tissues PERSPECTIVE Holistic precision wellness: Paving the way for next-generation precision medicine (ngPM) with AI, biomedical informatics, and clinical medicine ### About FASEB BioAdvances FASEB BioAdvances is an international, fully open-access journal that publishes high-quality biological and biomedical research. It emphasizes sound science, robust experimentation, and welcomes studies across a wide spectrum, including null findings and incremental advances. The journal covers topics from molecular biology to ecosystems, featuring research articles, reviews, and perspectives on key issues in academia and society.
Committed to open dissemination, FASEB BioAdvances makes science accessible to all. About FASEB FASEB is comprised of 22 scientific member societies with 110,000 members, making it the largest coalition of biomedical research associations in the United States. FASEB’s mission is to advance health and well-being by promoting research and education in biological and biomedical sciences through collaborative advocacy and service to member societies and their members.
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FASEB BioAdvances April 2025 Issue: Exploring the Intersection of Environmental Factors, Innovative Treatments, and Precision Medicine

The April 2025 issue of FASEB BioAdvances delves into the effects of global warming on obesity, innovative treatments for hypertension and kidney injury, gene recombination in neural tissues, and the future of precision medicine through AI and biomedical informatics.