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African Swine Fever (ASF) poses a grave threat to the swine industry, with the virus causing severe economic and agricultural disruptions since its emergence in China in 2018. The disease, transmitted by the African Swine Fever Virus (ASFV), has become endemic with a high mortality rate nearing 100%. Despite extensive efforts, the development of effective vaccines or treatments has been hindered by the virus's complex nature.
This urgency calls for innovative approaches to manage and mitigate the impact of ASF on pig farming communities. Researchers from Huazhong Agricultural University, in collaboration with the Hubei Jiangxia Laboratory, have published a comprehensive review (DOI: 10.1186/s44149-024-00122-1) in the journal Animal Diseases.
The study delves into the advancements of Traditional Chinese Medicine (TCM) in the prevention and control of ASF, highlighting the antiviral and immunoregulatory capabilities of herbal compounds. The comprehensive review meticulously details the multifaceted approach of TCM in addressing ASF. It underscores the antiviral potential of various herbal extracts, such as berbamine hydrochloride from Berberis amurensis Rupr.
, which inhibits ASFV proliferation by interfering with early viral infection stages. Luteolin, found in common vegetables like broccoli, has demonstrated the ability to suppress the virus's replication cycle by modulating key signaling pathways. The study also highlights the role of TCM in immunomodulation, showcasing how .
