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Endometriosis drug offers hope for sufferers who want children - because patients can get pregnant while being treated By LUKE CHAFER FOR THE MAIL ON SUNDAY Published: 01:19, 17 November 2024 | Updated: 01:26, 17 November 2024 e-mail View comments A new drug for womb disease endometriosis could offer hope for sufferers who want children. Called HMI-115, it dramatically reduces the agony caused by the chronic womb condition and – for the first time – patients can get pregnant while being treated. Endometriosis, which affects one in ten women, develops when tissue that lines the womb grows in other parts of the body.
It can cause bleeding, inflammation and, if left untreated, can lead to infertility. While drugs already exist which can reduce the debilitating symptoms, patients cannot get pregnant while taking them. Earlier this year a new hormone therapy, relugolix, was approved by the UK drug regulator after being shown to dramatically reduce the impact of symptoms.
However, it disrupts the menstrual cycle, meaning patients are unable to fall pregnant while on it. HMI-115 works by blocking production of a protein created in response to endometriosis, which is thought to trigger the pain that patients suffer. A new drug to treat endometriosis could offer hope to sufferers who want children, allowing them to become pregnant while being treated (file photo) Endometriosis affects one in ten women, and can cause bleeding, inflammation and lead to infertility if left untreated (file photo) In a trial, HMI-115 cut pain levels by an average of 42 per cent.
And, crucially, it did not appear to disrupt the menstrual cycle. ‘For the past 40 years, people have been calling for a new target that provides pain relief while bypassing sex hormones – we are answering that call,’ says Professor Rui-Ping Xiao who is leading the research from Tsinghua University in Shanghai. Hope Medicine, the Chinese pharmaceutical company that makes HMI-115, says it is planning to begin a larger global trial ‘as soon as possible’.
Patients with endometriosis wait, on average, more than eight years from the onset of symptoms to receive a diagnosis. Last week the NHS told GPs to send all women with suspected endometriosis for a hospital scan , due to worries that thousands of cases were being missed. Share or comment on this article: Endometriosis drug offers hope for sufferers who want children - because patients can get pregnant while being treated e-mail Add comment.
