Can depression increase the risk of Alzheimer's disease?

Can depression increase the risk of Alzheimer's disease?

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Listen to Story Alzheimer's disease is a progressive neurological disorder that primarily affects memory and cognitive function. In India, Alzheimer's is becoming increasingly prevalent due to the ageing population. An estimated 4 million people are affected by some form of dementia, with Alzheimer's being the most common.

Despite this, awareness and diagnosis rates remain low, leading to delayed treatments and inadequate care. Mental health plays a critical role in Alzheimer's disease . Studies show that mental well-being significantly impacts the progression of the disease.



Depression, in particular, has been linked to an increased risk of Alzheimer's. Dr Gorav Gupta, CEO & Senior Psychiatrist, Tulasi Healthcare, said that beyond its effect on emotions, depression has an impact on the structure and function of the brain. "The hippocampal region, which is involved in memory and learning, might shrink as a result of long-term depression, affecting cognitive performance," said Dr Gupta.

Cortisol, the stress hormone, is high in depression and leads to oxidative damage and inflammation, he added. Depression, in particular, has been linked to an increased risk of Alzheimer's. (Photo: Getty Images) "While a direct correlation between depression and Alzheimer's disease does not exist, it is clear that preserving mental well-being is crucial to reducing the risk overall.

Prompt therapy for depression can mitigate its long-term effects on the brain and reduce the likelihood of cognitive decline," said Dr Kapil Agarwal, Senior Consultant & HOD - Department of Neurology, Marengo Asia Hospital, Gurugram. In fact, people with a history of depression are at a higher risk of developing Alzheimer's later in life. Poor mental health can also accelerate cognitive decline in those already diagnosed with the disease .

Psychological distress and isolation, both common among elderly individuals, can exacerbate memory problems and worsen symptoms. Mental stimulation, social engagement, and early intervention for mental health issues like depression are vital to managing Alzheimer's progression. Furthermore, addressing mental health conditions in Alzheimer's patients improves their overall quality of life and may slow the rate of cognitive decline.

Indian healthcare is increasingly recognizing the need to integrate mental health support into dementia care. Early diagnosis, mental health management, and creating awareness about Alzheimer's and related conditions will help tackle the growing challenge posed by this disease in India..