Application of Real-World Evidence in Selecting CAR T in R/R MM

Video content above is prompted by the following: Chimeric Antigen Receptor (CAR) T-Cell Therapy in R/R MM Panelists discuss how real-world comparative analyses reveal nuanced differences in the efficacy and safety profiles of ciltacabtagene autoleucel and idecabtagene vicleucel among patients with R/R MM, highlighting the critical importance of translating clinical trial data into practical treatment strategies. Key Insights from Real-World Analysis The retrospective intention-to-treat analysis by Amoozgar et al presented at ASH 2024 (abstract #2408) offers several important perspectives: Real-World Efficacy Variations : Real-world studies demonstrate that CAR T-cell therapy outcomes can differ significantly from controlled clinical trial settings due to patient heterogeneity, comorbidities, and prior treatment histories. Comparative Performance : The study likely compared the efficacy and safety of 2 different CAR T-cell therapies (ciltacabtagene autoleucel and idecabtagene vicleucel) in actual clinical practice.

Patient Selection Implications : Real-world data help refine patient selection criteria and predict more personalized treatment responses beyond initial clinical trial parameters. Safety Profile Nuances : The analysis would have shed light on potential adverse events, treatment-related complications, and long-term tolerability in a more diverse patient population..