2 weeks Ago By Grace Browne
In 2018, Tom Finn took his father, Nigel, to a physiotherapy appointment. Nigel was living with vascular dementia, which can present with symptoms similar to Parkinson’s disease, a progressive neurological disorder characterized by motor symptoms such as tremors, stiffness, and trouble balancing. He was losing the ability to walk.
The physiotherapist told Finn about cue markers—colored lines laid on the floor that can help Parkinson’s patients overcome difficulty walking. Finn was unconvinced. He couldn’t see how some lines on the floor would help his father.
But when they got home, he laid some colored exercise bands down in the kitchen and watched in amazement as his dad easily marched back and forth across them. The technique, called external cueing, works by using visual, auditory, or tactile prompts—colored tape on the ground, playing a metronome, or physical vibrations —to engage neural pathways not affected by the disease. “It can help people focus their attention and help them take that first step and overcome the freeze,” says Claire Bale, associate director of research at Parkinson’s UK, a research and support charity in the UK.
While Finn—who worked in marketing and video production in London—was struck by the effectiveness of this simple intervention, he thought it too basic to actually be helpful. But augmented reality glasses from the likes of Magic Leap had just started coming to market, and he wondered whether they might be able to project virtual lines onto the ground to act as cues. He founded a startup, Strolll, to try to make that vision a reality.
Solving the Parkinson’s Puzzle Piece by Piece Using Good Vibrations to Restore Confidence in Movement Charco Neurotech is building wearable devices that vibrate at high frequency to provide physical cueing that can help lessen Parkinson’s symptoms. The Cambridge-based startup’s CUE1 device is already being used by thousands of people in trials. Sniffing Out the Right Candidates for Drug Trials Long-lasting smell loss is a surprisingly good predictor of brain disease.
A study funded by the Michael J. Fox Foundation used a scratch and sniff test to help identify potential carriers of a biomarker for Parkinson’s. Deep-Brain Stimulation for Real-Time Activity Adjustment Deep-brain stimulation works like a pacemaker, using electrical signals to alleviate Parkinson’s symptoms such as tremors.
Spanish startup Inbrain has raised $50m to develop graphene-based neural implants that can constantly monitor and modify brain activity in real time. Detecting the Visual Signs of Parkinson’s Disease As a teenager, Erin Smith created a program called FacePrint, which analyzes facial expressions in selfies to spot “Parkinson’s mask,” a tell-tale early sign of Parkinson’s disease. She won the WIRED Health Startup showcase in 2018.
Two years later, Strolll had no staff and about £50 in the bank, according to Jorgen Ellis. Ellis, a New Zealander with a background in furniture startups, had come to the UK looking for his next venture and wanted to get involved with something he felt passionate about. His grandfather had lived with Parkinson’s for over a decade, and when he met Finn through a mutual contact, he immediately saw the promise of the technology.
He came onboard as CEO and started by trying to demonstrate that AR-based cueing was scientifically valid. Ellis and Finn soon found a group of academics at VU University in Amsterdam, led by Melvyn Roerdink, who were working on something similar. Strolll acquired their intellectual property, and with Roerdink on board as chief innovation officer they began to develop and test the technology, now called Reality DTx.
Instead of physical bands like Finn used, Strolll’s AR software simulates colored lines on the floor in front of the wearer, with each line disappearing as they clear it. A clinical trial (supported by Strolll) confirmed the cueing technology was feasible and found promising outcomes. It could also help with rehabilitation exercises amid a shortage of physiotherapists: The software includes AR games like whack-a-mole and basketball, but designed around functional movements that help people with Parkinson’s.
Mark Ross—who was diagnosed with Parkinson’s eight years ago at the age of 36 and is now Strolll’s head of brand and creative strategy—says these games can help overcome the apathy and depression that’s also a symptom of the disease. “You might know that you’ve got to exercise ..
. but that’s not going to help you get off your chair,” he says. So the fact that it’s gamified makes doing the exercises much more alluring.
The Magic Leap headset the software runs on costs around £3,000 ($3,800), and Strolll charges upwards of £300 a month for its services—but Ellis argues this is more cost-effective than 30 half-hour sessions of in-person physical therapy. Ultimately, the company’s goal is to be the “most used rehabilitation software in the world,” says Ellis. They even have a specific timeline in mind: 7 million minutes of rehab with the Strolll device in a week by New Year’s Eve 2029.
By then, Ellis hopes Strolll could be in use for all kinds of neurological conditions, from stroke to multiple sclerosis. There is, he says, an “almost unlimited opportunity.” This article appears in the January/February 2025 issue of WIRED UK magazine.
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