49ers RB depth chart: Where Jordan Mason, Isaac Guerendo rank behind Christian McCaffrey in running back room

The 49ers might have the game's best running back in Christian McCaffrey. However, they'll be without him in Week 1 vs. the Jets, per NFL Network.

McCaffrey was listed as inactive around an hour prior to kickoff. A surprise: #49ers RB Christian McCaffrey is inactive tonight against the #Jets , sources tell me and @RapSheet . McCaffrey was listed as questionable after being limited in practice last week with calf/Achilles injuries.

McCaffrey had expressed confidence he would play. pic.twitter.

com/rLQMXVU3nR With the unexpected news, San Fransisco will turn toward its depth at running back in its first game of the new season. Here's a look at the 49ers' RB depth chart after the surprising news that McCaffrey will miss Week 1's game against the Jets. WEEK 2 FANTASY RANKINGS: QBs | RBs | WRs | TEs | D/STs | Kickers 49ers RB depth chart Rank Player 1 Christian McCaffrey 2 Jordan Mason 3 Isaac Guerendo 4 Patrick Taylor Jr.

1. Christian McCaffrey When he's playing, McCaffrey is one of the most dynamic weapons in NFL history. He played in 16 games last season, racking up 1,459 rushing yards and 21 total touchdowns.

However, he does have an injury history worth mentioning. McCaffrey played in just 16 games between the 2020-2022 seasons with the Panthers, and will now miss Week 1 of the 2024 season. McCaffrey was limited at practice throughout the week with a calf/Achilles injury, but he was still expected to play vs.

the Jets. Instead, the 49ers will look toward other players in the running back room to fill the void in Week 1. 2.

Jordan Mason After the news that RB Elijah Mitchell will miss the entire 2024 season when he was recently placed on IR, Mason became McCaffrey's official second fiddle. Mitchell has been around in San Fransisco for three seasons, usually serving as McCaffrey's top backup. However, a hamstring injury will keep him sidelined this season.

Mason, meanwhile, will step in as the starter for McCaffrey vs. the Jets. Over two years with the 49ers, Mason has 464 rushing yards and four touchdowns on 5.

6 yards per carry. The Georgia Tech product is in line to earn a good chunk of touches on Monday night, and if McCaffrey should miss any more time this season, Mason will continue to fill his role. 3.

Isaac Guerendo At RB3 for San Fransisco is Guerendo, a rookie drafted in the fourth round back in April. Guerendo played at Wisconsin and Louisville throughout his college career. His best season came in 2023 with the Cardinals, finishing with 810 rushing yards and 11 touchdowns.

The rookie won't start with McCaffrey out, but he should still see an uptick in snaps vs. the Jets on Monday. 4.

Patrick Taylor Jr. The final RB on the 49ers' roster is Taylor Jr., who spent the past three seasons with the Packers.

Taylor Jr. had a career-high 141 rushing yards last season in a packed Green Bay RB room. He has just one touchdown in his NFL career so far, which came in 2021, but he profiles more as a receiving back, as he had 11 receptions in his limited field time last season.

Taylor Jr. likely won't be a go-to guy for the 49ers even with McCaffrey out, but if either Mason or Guerendo also have to miss time, he could move up the depth chart..