Creams and lotions that promise to slow (if not stop) the hands of time abound, and the best serum for wrinkles is no exception. Powered by time-tested, science-proven ingredients like retinol and peptides , these formulations set out to soften the look of wrinkles, restore lift and support to sagging skin, and rebuild lost volume—and, in some cases, address other skin concerns related to aging, such as dark spots. That may seem like a tall order, but it’s entirely realistic, “especially when you use them consistently and invest in the right ones,” says Dr.
Tiffany Libby, MD , a board-certified dermatologist in Providence. Vogue ’s Top Serums for Wrinkles In This Article Those right ones can ultimately make a discernible difference in how your skin looks for years to come—which is why it helps to begin sooner rather than later. But it also helps to manage your expectations accordingly, since even the best antiaging serum can only do so much.
“It will not typically convert deep wrinkles into completely smooth skin, as there are limits to what a topical preparation can do,” says Dr. Gloria Lin, MD , a board-certified dermatologist in New York. With signs of aging being a common concern for many, beauty brands have answered in kind—meaning that the sheer volume of options on the shelf can make it challenging to determine the best serum for wrinkles for your individual needs.
With that, consider this curated variety to find the ideal option for you. Best Overall: SkinMedica TNS Advanced+ Serum Best Retinoid: Dr. Dennis Gross Advanced Retinol + Ferulic Treatment Best Growth Factor: Angela Caglia Cell Forté Serum Best Peptide: Medik8 Liquid Peptides Serum Best for Sun Damage: Alastin Restorative Skin Complex Best for Expression Lines: SkinCeuticals P-Tiox Wrinkle Serum Best for Sagging: Allies of Skin Multi Peptides and GF Advanced Lifting Serum Best for Sensitive Skin: 111Skin Repair Serum NAC Y2 Best Post-Procedure: Clinique Smart Clinical Repair Wrinkle Correcting Serum Best Drugstore: RoC Retinol Correxion Deep Wrinkle Serum Best Retinol Alternative: Isdin Melatonik Best for Crepey Skin: La Roche-Posay Rdermic R Retinol Cream Best Preventative: Cetaphil Healthy Renew Face Serum.
Entertainment
13 Best Serums for Wrinkles and Fine Lines

The best serum for wrinkles uses collagen-boosting ingredients like retinol, peptides, and hyaluronic acid. Shop our top picks for the best antiaging serums.